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SF also induces anti-inflammatory, heat shock-response (HSR)-inducing, and histone deacetylase (HDAC) inhibiting responses, contributing to its multifaceted cytoprotective effects (2, 13)

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Furthermore, Fer-1 mitigates oxidative stress by downregulating prostaglandin endoperoxide synthase 2 while upregulating GPX4 and Nrf2, thereby decreasing lipid peroxidation (115)

Nevertheless, IGF-I mRNA abundance is reduced in the brain of hypophysectomized rats and, intracerebral infusion of GH restores IGF-I mRNA to 80% of normal levels[70], which points out that GH has a clear role in modulating brain IGF-I