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On the therapeutic side, a Phase 1 clinical trial investigated MVT-602 a kisspeptin receptor agonist in women with PMOS and hypothalamic amenorrhea

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In 2000, the Fasano lab discovered zonulin as the analog of the prokaryotic zonula-occludens toxin (Zot) in primates ( Table 1 summarizes the different methods described above to evaluate intestinal permeability