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Each of these bile acids accounts for 40% of the bile acid pool in humans

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In HCC, tumor-derived soluble substances, including hyaluronan fragments, activate neutrophil autophagy through Erk1/2, p38, and NF-B signaling pathways, therefore extending neutrophil longevity, maintaining pro-metastatic factors such as MMP9 and oncostatin M, and facilitating tumor growth (178)

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Keene, B.W., ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs

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