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Intralysosomal iron induces lysosomal membrane permeabilization and cathepsin D-mediated cell death in trabecular meshwork cells exposed to oxidative stress

This ensures IV therapy is provided only when clinically appropriate and aligned with treatment objectives

Compared with the untreated cell line, the fluorescence changes of MT1G overexpressing GC cell line tended to the positive control group(CCCP) fluorescence changes, JC-1 polymer fluorescence decreased, and JC-1 monomer fluorescence increased (Fig

62 (26), Pl401407

This initiates the downregulation of antiapoptotic proteins via the downstream MAP-kinase kinase MKK4/MKK7/JNK and MKK3/MKK6/p38 pathways (Saitoh et al