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D3 benefits typically become apparent after 4-6 weeks of consistent supplementation, with bone health improvements taking several months to manifest

While the exact role of B cells in promoting the GVL effect remains unknown, these findings support the potential for B cell mediated cellular therapies or antibody therapy to enhance GVL

Example: 2 mg 5 mg/mL = 0.4 mL injection volume daily

These issues are interrelated, as slowed motility prolongs exposure to harmful substances, damaging the mucosa, while mucosal damage further impairs motility (28)

Even at the lowest maintenance dose of 5 mg, approximately 85% of participants lost at least 5% of their body weight