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We therefore sought to test whether NMN co-administration with the chemotherapy agents doxorubicin and cisplatin would impair the ability of these compounds to slow tumour growth in mice bearing an orthotopic xenograft of the highly aggressive, invasive and poorly differentiated triple-negative breast cancer cell line MDA-MB-231 (Fig

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The first rate-limiting step in the synthesis of both GSH and hGSH is the formation of -glutamylcysteine (-Glu-Cys) catalyzed by -glutamylcysteine synthetase (-ECS, encoded by GSH1 )

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Several randomized controlled trials tested oral glutathione at 250-500 mg daily