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Therefore, it is recommended that individuals at an elevated risk of bleeding, those taking specific anticoagulants and antiplatelet agents, and those undergoing surgical or other invasive operations should avoid it (Rosenblatt and Mindel, 1997)

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Next, the medium was replaced with DMEM/F12 with 10% FBS plus 25 mM D-glucose- 13 C 6 , and then the cells were treated with vehicle or 100 ng/ml bTNF- and incubated at 37 C and 5% CO 2 for 1 h