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pointed out that the overexpression of Wilms tumor 1 associated protein (WTAP) was significantly correlated with poor cancer prognosis, as it facilitated the EMT in GC cells by modulating TGF- expression and stability of mRNA, consequently leading to multiple chemotherapy resistance and metastasis (60)

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In addition, under conditions of hypoxia or nutrient deficiency, cancer cells can also use acetyl-CoA synthetase (ACSS) to obtain acetate, even when it results in the loss of a molecule of ATP

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Song J, Li J, Yang F, Ning G, Zhen L, Wu L, Zheng Y, Zhang Q, Lin D, Xie C, Peng L