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Peripheral nerve fibers supplying endometriotic lesions could sensitize spinal segment neurons and eventually lead to a central nervous system sensitization, resulting in an exaggerated central nervous system response or phantom-like endometriotic pain, or both, despite ablation of lesions (9)

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In this respect, the maintenance of the homeostasis of the CNS microenvironment is vital (3) and achieved by the presence of 3 main cellular barriers at the blood-CNS interfaces such as the BBB, the blood-cerebrospinal fluid barrier (BCSFB) and the arachnoid barrier (4) regulating nutrient flux, clearance of waste products, immune cell distribution and limiting the access of toxicants and pathogens