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Description

The in vitro release profile showed an initial burst of 29.3 4.0% of entacapone released from PEG-PLGA@Ent in the first 2 h, with a cumulative release of 39.7% over 72 h

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They are unstable in the presence of physiological concentrations of cysteine and GSH

ClinicalTrials.gov identifier: NCT03456700

Conclusion: Al-CPI modifies the transcriptome of moDC, increasing several transcripts encoding enzymes involved in cholesterol biosynthesis and SREBP signaling