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Among these, the NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) inflammasome plays a significant role in APAP-induced liver injury

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In phase three, resistance-trained males were randomly assigned to orally ingest either cellulose placebo (2.52 g/day), L-citrulline (2 g/day), GSH (1 g/day), or L-citrulline (2 g/day) + GSH (200 mg/day) for 7 days, and then perform a resistance exercise session involving 3 sets of 10-RM involving the elbow flexors

Two-way ANOVA followed by the Bonferronis post hoc test was used to determine significant differences in behavioral tests

These perturbations unfold within minutes and precede measurable changes in microbial composition, indicating the involvement of regulatory mechanisms capable of fast, local control