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Mice had access to food and water ad libitum, except during the behavioural tests

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1bk), further supporting that the direct interaction of MeCbl with GSDME prevents its cleavage of the latter and represents the primary mechanism of MeCbl in inhibiting pyroptosis

These grading scales include the Ajani Sensory, Eastern Cooperative Oncology Group (ECOG), National Cancer InstituteCommon Terminology Criteria for Adverse Events (NCICTCAE), and World Health Organization (WHO) systems, which grade CIPN severity on a scale of 0 (normal) to 5 (death)

This can sometimes lead us to a genetic mutation called methyl-tetrahydrofolate reductase, or MTHFR