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D'Angelo and Selhub, 1997)

Pharmacological studies indicate that extracts from these plants exert therapeutic effects against PD through mechanisms such as antioxidant and anti-inflammatory actions, inhibition of -syn aggregation, preservation of dopaminergic neuron survival, and restoration of synaptic function ( in vitro cell experiments and in vivo animal models)

Aspartame induced a small but statistically significant increase in DNA strand breaks according to the alkaline comet assay in bone marrow of mice exposed to a single oral dose at 35 mg/kg bw by gavage (Bandyopadhyay et al., 2008)