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Research weve reviewed indicates that doses between 100mg and 200mg will cover the majority of potential CoQ10 benefits, with smaller doses running the risk of being too weak and larger doses running up against the U-shaped curve we described earlier essentially that higher doses begin to perform worse than lower ones.24 So, for most people, that 100-200mg range is ideal, making a 100mg softgel the best vehicle for CoQ10, as it allows for easy dose adjustment between 200mg and 100mg if desired