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Current science has shown that pasteurization has a negative effect on the nutritive qualities of milk, and the impact is not inconsequential

Damage-associated molecular patterns, such as high mobility group box 1 (HMGB1), initiate this phenotypic shift by engaging signaling pathways like toll-like receptor 4 (TLR4) and the receptor for advanced glycation end products (RAGE), which in turn activate downstream effectors, including nuclear factor kappa-B (NF-B) and the NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome (Tastan and Heneka, 2024

Conversely, leptin receptor deficient db/db mouse model of type 2 diabetes demonstrated increased BBB permeability, as compared to db/+ control mice (Yu et al., 2019)