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Name: l carnitine hcl L-Carnitine – Hero Supplements It is distributed throughout the central and peripheral nervous system C10:0 L-carnitine (HCl salt) 870337P
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Description

Acta 1762, 10011012

Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)

Methods: A systematic scoping review following PRISMA-ScR guidelines searched PubMed, MEDLINE, CINAHL, CENTRAL, and IEEE Xplore for quantitative studies (2014-2024)