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The comet assay in association with gamma-H2AX foci showed DNA injury, and the overexpression of Bax and PARP1 cleavage showed cellular apoptosis after the combination treatment

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The GLP-1 receptor limb Through GLP-1R engagement, survodutide is expected to reproduce the familiar incretin effects: glucose-dependent enhancement of insulin secretion, suppression of inappropriate glucagon release in the fed state, delayed gastric emptying, and central appetite suppression that reduces energy intake

*Correspondence: Oliver Werz, Institute of Pharmacy, University of Jena, Philosophenweg 14, D-07743 Jena, Germany

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