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Description

Int J Biol Sci 11:12961305

Clinical observations by Hong et al

The present findings seem to be consistent with other research that found the up-regulation of most amino acids in thyroid carcinoma tissue compared to normal tissue ( Another important finding was that there were significant changes in metabolites related to the TCA cycle, particularly glutamic acid and -ketoglutarate, in patients with thyroid nodules compared to healthy subjects

Molecular crosstalk under fatty acid metabolism dysregulationsuch as lipotoxicity, mitochondrial damage, immune inflammation, epigenetics, metabolic reprogramming, and the gut-kidney axisdrives damage to renal tubules, glomeruli, and the interstitium