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Kantarjian HM, O'Brien S, Cortes JE, Smith TL, Rios MB, Shan J, Yang Y, Giles FJ, Thomas DA, Faderl S, Garcia-Manero G, Jeha S, Wierda W, Issa JP, Kornblau SM , Keating M, Resta D, Capdeville R, Talpaz M

Stahl W, Sies H

found that the transcription factor ChREBP can also promote BCKDK and inhibit PPM1K expression to inhibit BCKDH activation and promote ATP citrate lyase (ACLY) activation, upregulate the lipid synthesis pathway, and induce hepatic steatosis in the obesity model of high-sugar diet

The PCR was performed on genomic DNA isolated from individual colonies with the primers flanking the GPX2 gene sequence ( GPX2 _F: 5- TGATGGGGCAAGTAGGAGTC-3, GPX2 _R: 5- CCACACCTGCCCTTTATTGG-3)