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No human safety data : The complete absence of human clinical trials means the safety profile, side effects, optimal dosing, and pharmacokinetics in humans are entirely unknown Animal-to-human translation is uncertain : Metabolic differences between mice and humans mean that the magnitude of effects (e.g., weight loss, grip strength improvement) may not translate

What to Expect During Recovery Once treatment begins, recovery typically follows this timeline: First Few Days to Weeks: Many people notice an increase in energy and improvement in symptoms like fatigue and weakness within the first week of treatment

People with gastrointestinal issues that affect B-12 absorption, like Crohns disease or celiac disease, pernicious anemia, a history of stomach or bariatric surgery, or heavy alcohol use, may also be at risk for low B-12 levels

Isaac Bogoch, an infectious disease specialist at the University of Toronto