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Besides contributing to the increase of tumour mass, the rewiring of cholesterol and sphingolipids metabolism alters the composition of lipid rafts that play an important role in other hallmarks of cancer such as oncogenic signalling, migration, proliferation, adhesion, invasiveness, metastatic spread, apoptosis evasion [51], vesicular trafficking and drug resistance [52]

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Therefore, modern research on TCM advocates a holistic approach, starting from the principles of "recognizing properties through effects, unity of properties and effects, and mutual reflection of properties and effects." This approach involves studying the pharmacological effects in relation to the main chemical components and clinical research in modern pharmacology, enriching our understanding of the properties of ginger from a modern perspective, and also supplementing areas that have not yet been recognized from the standpoint of modern scientific technology (see Fig

and (vi) vesiculation of irreversibly damaged components ( Steap3, APOs, Mon1a mapping guanosine phosphate pools)

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