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Rat studies have noted embryofetal mortality, structural abnormalities, and alterations to growth at maternal exposures below the maximum recommended human dose (MRHD) based on exposure AUC

Kurtis Martin and his team.

A 2019 study published in Frontiers in Endocrinology looked at over 9,000 adults and discovered that serum B12 concentrations were lower among obese adults than non-obese adults 7

In the absence of impaired kidney function, an elevated MMA level in conjunction with elevated homocysteine suggests either a vitamin B 12 deficiency or a combined vitamin B 12 and folate deficiency (32)