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Definition Sciatica refers to pain, weakness, numbness, or tingling in the leg

Mechanisms by which PPIs, H2RAs, and metformin affect serum total vitamin B-12 concentrations PPIs and H2RAs are 2 classes of drugs that are used to treat conditions associated with excess gastric acid production, including dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, Barrett esophagus, and Zollinger-Ellison syndrome

ALA does not replace B12, and B12 does not replace ALA