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Although this study revealed that the inhibition of mGluR5 in normoxia did not induce any change, another study found that the Riluzole treatment in normal conditions inhibited proliferation, induced apoptosis, and prevented migration of human osteosarcoma LM7 cells (76)

Burke MD, Mayer RT (1983) Differential effects of phenobarbitone and 3-methylcholanthrene induction on the hepatic microsomal metabolism and cytochrome P-450-binding of phenoxazone and a homologous series of its n -alkyl ethers (alkoxyresorufins)

RNA expression profiling also showed a significant increase in CDKN1A (p21), a p53 target gene coding for a cell cycle inhibitor, together with a decrease in the transcription of CCND1 , CCNE1 and Myc