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S1 as upregulated and downregulated GOBP with significantly affected proteins as input for enrichment

While the depletion of the cellular energy metabolism is the main effect during the first ischemic phase, inflammation and oxidative stress are predominant during reperfusion (second phase)

On the other hand, treatment of cancer cells with the anti-IGF-IR mAb cixutumumab paradoxically triggers cancer cells to produce IGF2, which in turn recruits macrophages and fibroblasts to promote angiogenesis and metastasis thereby hampering the efficacy of cixutumumab [190]

Hypoxic conditions (1% O 2 and 5% CO 2 ) were established using a 9000EX CO 2 incubator (Wakenyaku Co., Ltd.), with oxygen levels monitored and maintained according to the manufacturers instructions

Current scientific studies link intestinal permeability with inflammatory bowel disorders, gluten sensitivity, celiac disease, Crohns disease, type 1 diabetes, depression, anxiety, psoriasis, and many other chronic conditions