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In the absence of validated protein, metabolite or genetic markers in CSF or blood, identifying patients most likely to benefit from ferroptosis-targeting therapies, assessing the treatment response or dose adjustment are difficult (9)

The accelerated drug approval introduced by the FDA in 2024 was probably made possible by growing acceptance of precision medicine and genetic screening in targeted therapies, for instance, those for non-small-cell lung cancer and pancreatic adenocarcinoma, by approving zenocutuzumab-zbco (brand name Bizengri , and for transthyretin-mediated amyloidosis causing cardiomyopathy and heart failure, by approving acoramidis (brand names Attruby and Beyonttra, The P4 medicine paradigm continues to demonstrate its value across chronic diseases, even as attention increasingly shifts toward rare disorders

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However, to get further insight in the role of SLC35A39 in the brain, the generation of specific conditional Slc25a39 knockout mice that carry a deletion of Slc25a39 exclusively in neurons or in the central nervous system may further boost our understanding on the roles and in the importance of SLC25A39 in neuronal tissues