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Histamine : Causes blood vessel dilation, increased mucus production, and itching Prostaglandins (particularly PGD2) : Contribute to inflammation in airways Leukotrienes : Potent contributors to airway constriction (LTC4, LTD4, LTE4) Cytokines : Signal other immune cells to join the response (IL-4, IL-5, IL-6, IL-13) Tryptase : Promotes inflammation and tissue remodeling This is why blocking just one pathway like antihistamines do often isn't enough

The study found that CoQ10 monotherapy did not significantly reduce symptoms compared to a placebo, highlighting that a single nutrient may not be enough to overcome deeply entrenched mitochondrial dysfunction

Since, I've also started one of their many weightloss program options

Impaired autophagy results in the accumulation of -syn, mitochondrial dysfunction, and exacerbated neuroinflammation, thereby accelerating PD progression (Bayati and McPherson 2024)