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Epstein-Barr virus infection induces indoleamine 2, 3-dioxygenase expression in human monocyte-derived macrophages through p38/mitogen-activated protein kinase and NF-B pathways: impairment in T cell functions

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When this happens, the virus can trigger inflammation in the nerve fibers, which leads to the most common complication of shingles: postherpetic neuralgia (PHN)