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Typically, migraines are characterised by periodically recurring, pulsating, half-sided headaches, which can be accompanied by symptoms such as nausea, vomiting and sensitivity to light and noise

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The relationship between the probability score of a participant being positively diagnosed with advanced COPD and the log 2 intensity value of each protein marker was defined as follows: Combining scores from 3 metabolites and that of 1 protein resulted in a high auROC value of 98.0%, with a sensitivity of 94.0%, and specificity of 95.0% (Additional file 9: Table S4)