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Primary mechanistic drivers encompass adipogenic dysregulation, cellular senescence programs, and aberrant adipokine signaling networks (401, 402)

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531 In osteosarcoma cells, zinc oxide nanoparticles can also be observed to increase the expression of HIF-1, mediate mitophagy through the HIF-1-BNIP3-LC3B pathway, and inhibit tumor growth, 532 along with tumor cell metastasis