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We cannot provide the biological significance to reconcile the apparent incongruence between the low-metabolites association with PsA as disease and its positive correlation with the activity score (e.g

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Ginseng can also activate the reperfusion injury salvage kinase (RISK) signaling pathway through glucocorticoid receptor/estrogen receptor (GR/ER) in an endothelium nitric oxide synthase (eNOS)-dependent mechanism (Zhou et al., 2011)

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