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Clinical assessment and full blood count showing macrocytic anaemia are also important, though neurological symptoms can occur without haematological changes

The genetic association observed appears to be equally applicable regardless of gender, though there was a significantly higher percentage of female participants in the case vs control group (Table 1)

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8,31 However, the underlying basis for this is complex, particularly because alcohol use, smoking, genetic variants of the MTHFR gene, and other factors can interfere with folate metabolism