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The duration of the trial was three years with 3862 patients exposed to Reclast and 3852 patients exposed to placebo administered once annually as a single 5 mg dose in 100 mL solution infused over at least 15 minutes, for a total of three doses

PAD, peripheral artery disease

Additionally, polyol pathway activation in the retina of diabetic rats shows increased lipid peroxidation products and depletion of antioxidant enzymes, suggesting that retinal cells and more specifically neuronal cells might be more prone to oxidative stress induced by the polyol pathway early in diabetes (Ola et al., 2018)

This is a common characteristic of natural-origin PSs, which typically lack strong redox-active functional groups such as phenolic or flavonoid moieties, the key constituents of standard antioxidants