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Taken together, these studies demonstrate that the loss of CTH in macrophages leads to metabolic suppression and impaired immune activation that underlies the decrease in H

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Adv Drug Deliv Rev 64:640665 Chen Y, Shan X, Luo C, He Z (2020) Emerging nanoparticulate drug delivery systems of metformin

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Depletion of Tregs in mice has been associated with increased anxiety-like behaviors and elevated levels of inflammatory cytokines, suggesting that Tregs may help attenuate the effects of neuroinflammation on mood [173,179]