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Singh et al., 1989)

With these losses, the proliferation of activated T cells declines significantly [88]

Kamada K, Goto S, Okunaga T, Ihara Y, Tsuji K, Kawai Y, et al

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Both conditions feature elevated prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) via Cyclooxygenase-1 (COX-1)/Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) activation, respectively, which amplify neuroinflammation (microglial activation) and synovial inflammation (fibroblast activation) (200, 302)