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10.1515/revneuro-2020-0099 44 LiuT.ZhongS.LiaoX.ChenJ.HeT.LaiS.et al (2015)

The IGF-1R has a similar structure to the insulin receptor

This includes monitoring IGF-1, IGFBP-3, and GH stimulation parameters, and designing a protocol that restores optimal GH axis function across all its effects: muscle, fat, sleep, skin, connective tissue, and metabolic health

We highlight key E3 ubiquitin ligases and deubiquitinating enzymes (DUBs) that modulate the abundance of core clock components and their downstream effectors and discuss how disruptions in these processes can lead to circadian misalignment and disease