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Recent work has also indicated that BSO can potentiate the toxicity of TMZ-induced bystander effect on glioblastoma cells 36 and a GSH transferase inhibitor was shown to potentiate the cytotoxic effect of TMZ in melanoma cells

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Innovative technologies that enable targeting of undruggable targets include targeted protein degradation, such as proteolysis-targeting chimera (PROTAC) molecules that can degrade a target protein by controlling the ubiquitinproteasome system