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The antiferroptotic effects of metformin were phenocopied by its fecal microbiota but were eliminated by antibiotic intake

4 ShadadAKSullivanFJMartinJDEganLJ

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typically relates to preliminary studies that show a novel treatment has the desired effect or works via the purported mechanism

Transforming growth factor-1 (TGF-1) can induce the EMT phenotype in melanoma cells and upregulate the levels of GPX4 and SLC7A11, while gambogenic acid, a xanthone derived from traditional Chinese medicine Gamboge, can promote ferroptosis by inhibiting the SLC7A11/GPX4 pathway in melanoma cells stimulated by TGF-1