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In this review, we summarize both classical mechanisms and recent discoveries, with a focus on novel perspectives such as cellular heterogeneity, the roles of metabolites [Figure 1], and intercellular communication [Figure 2]

This is why a balanced, and often, combined approach is the most effective

Can be combined with other treatments (such as Botox for crows feet or frown lines) for a balanced facial appearance

The single production yield of this method is usually only in the range of milligrams to grams, which cannot meet the efficiency and output requirements for industrial applications