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Interestingly, these authors identified 43 robust target genes of these regions, thus showing that the expression of more than one gene is influenced by these polymorphisms

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In 1993, da-Silva (228) showed that BAC peaked later and that the mean area under the BAC-time curve (AUC), an indicator of systemic availability of the drug, was significantly smaller in lactating women when compared to a control group

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Secondly, the introduction of the Fc fragment allows the downstream purification process to utilize antibody purification techniques, making the downstream process relatively more efficient