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Motivated by these initial observations, we reasoned that the nutritional status might shape pathological processes in a genetically tractable model organism carrying a pathogenic AIF variant, thereby defining the eventual relevance of diet-derived metabolites in disease etiology

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10.1186/s13073-017-0451-z 36 BenakisC.BreaD.CaballeroS.FaracoG.MooreJ.MurphyM.et al

Acrolein has been reported to induce transcriptional activation of ARE-dependent genes, resulting in the upregulation of phase II enzymes and cytoprotection against electrophile stress

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