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Apixaban's pharmacokinetics are not meaningfully altered by glucose or insulin fluctuations, so this pathway is not clinically concerning for the interaction question

Prenatal diagnosis has been preformed in glutathione synthetase deficiency

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Panneerselvam, K

Given that an increase, but not a decrease, in the Kyn/Trp ratio is expected to be associated with inflammation, and that we observe a one-directional trend towards increased values among the asymptomatic V30M carriers compared to controls (Table 2