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DlSEP1 and 3 seem to account for a major position of E function due to their wider and higher expression level

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In addition to receptor distribution, we found that LPS binding to TLR4 activated the NF-B-ARHGEF3-RhoA pathway, promoting actin filament assembly and DLPs formation in macrophages, which enhanced their capacity to capture bacteria

The case of metformin inducing melanoma ferroptosis through the activating transcription factor 3/nuclear factor erythroid 2related factor 2 axis aligns with findings that dichloroacetic acid triggers ferroptosis in CRC stem cells through lysosomal iron chelation [148]

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