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Discussion The main findings of our study in swine are that while DM alone substantially impacts cardiac hemodynamics, with elevated cardiac pre- and afterload provoking elevated coronary blood flow at rest which compromises coronary flow reserve, but also maladaptive cardiac remodeling with diastolic, systolic, and mitochondrial dysfunction, the addition of CKD causes no or little additional compromise on these parameters

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Those with sulfite allergies are more prone to sulfide minerals sensitivity in general, including to sulfates

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