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4 integrates extracellular stress and growth cues to regulate cell-cycle progression, apoptosis, and differentiation, and frequently cooperates with NF-B signaling to promote cancer cell survival and metastasis

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RibeiroJMMaculanGvilaBMoraisVHoeckesfeldLSecchiLet al

After M1 polarization, macrophages release large amounts of Fe 2+ via ferritin autophagy mediated by nuclear receptor coactivator 4 (NCOA4), which not only promotes ferroptosis but also causes the further release of ferroptosis-promoting factors into the cornea, RPE, and RGCs, forming a vicious cycle in the ocular microenvironment

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