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Necroptosis has been shown to be strongly associated with vitiligo, as melanocytes from perilesional skin affected by vitiligo were significant for necroptosis markers, such as phosphorylated RIP3 and a phosphorylated mixed-lineage kinase-like domain

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In terms of receptor activation, chlordane+PCB126 activated hepatic xenobiotic receptors, namely CAR ( Cyp1b10 ) and AHR ( Cyp1a2 ) but PXR ( Cyp3a11 ) was activated only in males, implicating how sex+HFD interactions impact these receptors as potential drivers of toxicant-induced hepatic metabolic disruption and possibly injury

Nuclear recruitment of neuronal nitric-oxide synthase by alpha-syntrophin is crucial for the induction of mitochondrial biogenesis