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Medical Microbiology and Immunology, 194 (12), 5559

In: Lewin GR, Carter BD (eds) Neurotrophic factors

Selection of offspring based on specific genetic markers at each successive generation can speed this process such that a congenic strain of mice is produced in as little as 5 backcross generations DNA methylation: The chemical modification of genomic DNA occurring in many eukaryotes (particularly mammals) in which methyl (CH 3 ) groups are added to cytosine bases as a mechanism of inducing heritable changes in gene function without a change in DNA sequence (i.e., epigenetic changes)