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Trials 24 (1), 449

doi: 10.1021/acsomega.3c03055 67

Figure 4 These molecules could self-react with ROS, but the removal efficiency is higher in enzyme-mediated reactions, like those catalyzed by APX (EC 1.11.1.11), ascorbate oxidase (AscO, EC 1.10.3.3), SOD, catalase (CAT, EC 1.11.1.6), and GPx (EC 1.11.1.9

Such studies could advance our understanding of the molecular mechanisms underlying GR homeostasis dysregulation in various pregnancy disorders and lead to novel strategies to prevent or reverse these molecular changes, ultimately paving the way for optimized perinatal glucocorticoid therapies in the era of precision medicine

NOX serves as a prominent source of ROS in the central nervous system, and its isotypes are widely distributed across brain, especially in key structures involved in learning and memory