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The moderately strong effect size (Hedges g = 0.67) across multiple randomized controlled trials places oxytocin research on relatively firm ground, though questions about optimal dosing, frequency, and long-term effects remain active areas of investigation

Xiong et al., 2018

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C.da Motta SilveiraF

As expected, the strictly conserved Asn419 hTrxR1 appears to be the most important residue for aligning the flexible C-terminal arm during catalysis, because a simultaneous mutation of all three guiding bar residues (Trp407 hTrxR1 , Asn418 hTrxR1 , and Asn419 hTrxR1 ) led only to a minor increase in hTrx1- and DTNB-reduction activity of hTrxR1 compared to the mutation of Asn419 hTrxR1 alone (Table 2)