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Similarly, although some data suggest that THRB gene variants may affect thyroid hormone action and contribute to immune dysregulation, these findings have not been consistently replicated, highlighting the need for further well-powered studies in diverse cohorts (Table 2)

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Nakamura H, Sekiguchi A, Ogawa Y, Kawamura T, Akai R, Iwawaki T, et al

Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients

Taken together, COPD patients suffer from exaggerated inflammation, increased oxidative stress, and impaired host defense